A Rational Approach for the Identification of Non-Hydroxamate HDAC6-Selective Inhibitors
نویسندگان
چکیده
منابع مشابه
A Rational Approach for the Identification of Non-Hydroxamate HDAC6-Selective Inhibitors
The human histone deacetylase isoform 6 (HDAC6) has been demonstrated to play a major role in cell motility and aggresome formation, being interesting for the treatment of multiple tumour types and neurodegenerative conditions. Currently, most HDAC inhibitors in preclinical or clinical evaluations are non-selective inhibitors, characterised by a hydroxamate zinc-binding group (ZBG) showing off-...
متن کاملthe use of appropriate madm model for ranking the vendors of mci equipments using fuzzy approach
abstract nowadays, the science of decision making has been paid to more attention due to the complexity of the problems of suppliers selection. as known, one of the efficient tools in economic and human resources development is the extension of communication networks in developing countries. so, the proper selection of suppliers of tc equipments is of concern very much. in this study, a ...
15 صفحه اولRational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors.
A mini library of HDAC inhibitors with peptoid-based cap groups was synthesized using an efficient multicomponent approach. Four compounds were identified as potent HDAC6 inhibitors with a selectivity over other HDAC isoforms. The most potent HDAC6 inhibitor revealed remarkable chemosensitizing properties and completely reverted the cisplatin resistance in Cal27 CisR cells.
متن کاملthe effect of a selfregulatory approach on the improvement of efl learners listening comprehension
تاثیر آموزش مهارت خود محوری بر روی ارتقاء مهارت شنیداری زبان آموزان هدف این پژوهش بررسی عوامل موثر در ارتقا مهارت شنیداری زبان آموزان ایرانی بود. در مرحله اول این تحقیق پژوهشگر پس از انجام مصاحبه نود زبان آموز را با استفاده از تست ایلتس انتخاب شدند. برای بررسی عوامل عوامل موثر در ارتقا مهارت شنیداری زبان آموزان ایرانی از دو نوع فیلم ویرایش شده و ویرایش نشده استفاده گردید.برای انجام تح...
HDAC6: physiological function and its selective inhibitors for cancer treatment.
Acetylation and deacetylation of histones are important in regulating gene expression and play a key role in modification of gene transcription. Specific HDACs isoforms can be regarded as a target for cancer therapy avoiding side-effects, HDAC6 with a unique physiological function and structure has become a hot issue recently. The unique isoform HDAC6 is involved in tumorigenesis, development a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep29086